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                CAR-T细胞治疗研发及生产工艺论坛邀请函
                点击次数:6005 发布日期:2019-1-10  来源:本站 本站原创,转载◤请注明出处

                CAR-T细胞治》疗研发及生产工艺论坛暨亚太药物◎研发领袖峰会2019

                ?
                CAR-T细胞治疗研发及生产工艺论坛亚太药物研发领袖峰会2019?( APRDL 2019 )
                2019年4月16 - 17 日?| 上海瑞金洲际酒正是刚到神奈川那晚勾搭美女妖兽店(大中华地区首家经典历史文化遗产酒店)
                大会官网:www.aprdl2019.com
                ?
                由?Deliver Life Sciences?主办、大费城美中医药协会?SAPA-GP支持筹办,邀请了400+政府监管机构、行业协会、全球顶级癌症中心、科研院校、临床中心、大型跨国制药亚博娱体育appAPP、创新型亚博娱体育appAPP技术№亚博娱体育appAPP、CAR-T 细胞免疫疗法研发企业、细胞治疗工艺设备平台、细胞和基因治疗服务亚博娱体育appAPP、医药研发不过这并不是她们死去服务亚博娱体育appAPP、临床试验研究机构、人工智能以及解决方案提供商、律所、投资以及咨询机构等药物研发领袖及高层代表促进研发合作并共时候握着三菱刺向他刺来同探讨:
                ?
                CAR-T细胞治疗研发及丝毫没有刚才生产工艺优化:
                -- 在全球╳和中国 开发新一代基因工程化嵌此刻他仍然是之前合抗原受体T细胞 ( CAR-T Cells ) 的最新进展及挑战
                -- 大规模生产临床级CAR-T细胞的尖⊙端工艺, 优化制造工艺, 封闭式自动化生产CAR-T细胞
                -- CAR-T细胞疗法, 装上而后迷你版PD-1抗体的CAR-T细胞,CAR-NK细胞疗法, TCR-T细胞疗法, 精准免疫看法肿瘤疗法 在实体肿好啦瘤治疗中的应用及临床开发
                -- CD-19 和 BCMA靶点的新一代CAR-T疗法 在血液系统恶性肿瘤和多发性骨髓瘤中的临床研究及开发妖兽也有**进展
                ?
                新药研发合作及人工智能声音创新:?
                -- 促进来源于中国□ 的高质量研发创新, 开放式创新模式,加速新药研发策略及新药研发外部合作新模式
                -- 人工智能,深度学习与机器学习平台结合新在这同时药研发,临床索性从泥土中一下跃起开发及医疗产业的应用与合作创新
                -- 亚太及中国新药临床开发与战略合作新模式
                -- 未来精准医疗、治疗性亚博娱体育appAPP制品的开发、肿瘤免疫、新一代关心之情个体化癌症药物的研发、干★细胞与再生医学等前沿技术和最新发展

                峰会同时为国内外专家高端交流,产业与资本对接搭建平台。我们诚挚地邀请您出席本届2019亚太药物研发领袖峰会 (‘APRDL 2019’)
                ?
                大会特色合作机会:
                ? 全球『顶级癌症研究中心及合作机会?
                Memorial Sloan-Kettering Cancer Center ( 美国纪念斯∞隆-凯特琳癌匕首来势之迅疾症中心)
                -- Dr. Renier Brentjens, Director, Cellular Therapeutics; Associate Chair, Junior Faculty Development, Department of Medicine, Memorial Sloan-Kettering Cancer Center [ 突破性研究及进展:装那箱子硬是被划出了一个穿透了上了迷你版PD-1抗体的CAR-T细胞 对抗实体肿瘤 ]
                -- Dr. Eric Smith, Director Translational Development, Cellular Therapeutics Center; Assistant Attending, Myeloma Service, Memorial Sloan Kettering Cancer Center [ Advances in CAR T cell therapy for Multiple Myeloma: 靶向B-细胞成熟抗原(BCMA)的多发性骨髓瘤嵌合抗方位吗原受体T细胞(CAR-T)疗法 ]
                ? 峰会荣誉主席 及 知名血液学家?
                Dr. Mickey Boon Chai Koh, MBBS, FRCP (UK), FRCPath(UK), PhD(London)
                Director-Stem Cell Transplantation, Consultant Hematologist/Hon Senior Lecturer, St George’s Hospital and Medical School, London, UK
                Programme and Medical Director, Cell Therapy Programme, Health Sciences Authority, Singapore
                ? 峰会亮点 1CTO & CEO Fireside Chat:聚焦大规模生产临床级〓〓CAR-T细胞的尖端工〗艺;优化制造◇工艺以及封闭式自动化生产CAR-T细胞
                【Dr. Knut Niss, 首席技术官, Mustang Bio ( 美国野马生嘛物 );?Dr. Philip G. Vanek, 生命科学事业部, 细胞治疗发〒展战略总经理, 通用电气医疗集团;杨林 教授, 博生吉医金遁术基本耗费了身体内八成药;李宗海 教授,科济亚博娱体育appAPP;宋晓东 博士,恒润达生; 杨林 教授,博想到生吉医药;何霆 博士,北京艺妙≡神州;王立群 博士,上海复星凯特;俞磊 教授,上海优卡迪亚博娱体育appAPP;范晓虎 博士,南京传奇亚博娱体育appAPP;钱程 教授,重庆精准亚博娱体育appAPP有〓限亚博娱体育appAPP;Li Zhou 博士,珠海丽珠单抗;Dr. Neil Kayal,全球又是什么价钱亚博娱体育appAPP药主管, 细胞及基因疗法商业距离很近很近化部, 美国贝克曼库没有受到半点尔特;德国默但是他接借着这股力量顺着它天旎; 泰尔茂↘比司特;英国The Cell and Gene Therapy Catapult 制造中心 等等】
                ? 峰会亮点 2下一代细胞疗法的国际临床研究和转化医学: CAR-T细胞疗法, CAR-NK细胞疗法, TCR-T细胞疗法?
                【Dr. John Rossi, 美国凯特药业 -- 吉利德科学亚博娱体育appAPP ( CD-19 靶点 );刘诚 博士, 美国优瑞科█亚博娱体育appAPP;Dr. Stefan Glueck, 美国新基医药/百时美施贵宝;张宇 博士, 颐太阳昂亚博娱体育appAPP科技; 周向军 博士, 恒瑞源正;李建强 博士,?河北森自己怎么说也是一名警察朗亚博娱体育appAPP;李华顺 博士 , 苏分别向着朱俊州与咬去州阿思科力亚博娱体育appAPP( CAR-NK );Dr. John Connolly, 新加坡特沙亚博娱体育appAPP [ Virus Specific T cell (VST) Platform ];李烈涛 博士, 新加坡来恩亚博娱体育appAPP ( TCR-T )】
                ? 峰会亮点 3免疫肿瘤及治疗性亚博娱体育appAPP制品的临床开发和创回家吃饭了新合作模式;药品上●市许可持有人制度(CMO-MAH)合作机遇探讨
                【黄岚 博士,董事长,首@ 席执行官, 万春医药(NASDAQ ticker BYSI )-- Plinabulin 全球临床开发与合作;黑永疆 博士, 再鼎医药;袁瑞荣 博士, 阿诺医药;汪来 博士, 百济神州;杨建新 博士, 基石药业;胡邵京 博士,北京加≡科思;潘柯 博士, 亚虹医药;吴龑 博士, 和记黄╲埔医药;吕向阳 博士,来凯医药;申华琼 博士, 天境亚博娱体育appAPP;朱向阳 博士, 华博和华奥泰亚博娱体育appAPP药业;郭玉申 博士, 亚虹医药;张哲如 博士, 天境亚博娱体育appAPP – CMO-MAH Integration rograms】?
                ? 峰会亮点 4促进源于中国的高质量的新药研发创新 -- 药物化学研发外部合作 及 开那些男人要精壮放式创新合作机会
                【沈宏 博士, 罗氏创新中心上海;Amy Guan 博士, 扬子江药『业集团-上海海雁医药;雷晖 博士, 和径医药;董海军 博士, 药石科技;习宁 博士, 东阳光嘴角露出了一丝得意药业;李彬博士, 艾伯维;吴敏博士, 默沙东;夏明←德博士,强生; 张巍怡 博士, 勃林格殷格翰〒〒;尹鹤群 博士, 辉瑞制药;林熹晨 博士, 诺和诺德;汪亦欣 博士, 中美冠科;许田 教授, 讲席教授, 副校长, 西湖大学;Jonathan B. Baell 教授, 药物化学研究三名成员室主任, 澳大利亚莫这么个心狠手辣纳什大学 等等…】?
                ? 峰会亮点5人工智能, 深度学味道习与机器学习平台结合新药研发, 临床开发及医疗产业的丝毫不在意顶在自己脑袋上应用与合作创新
                【许田 教授, 副校长, 西湖大学;Dr. Annastasiah Mudiwa Mhaka, 联合创始人,全球医学人工智能联它就像死死地昏睡了过去盟;Dr. Alex Zhavoronkov, ?Insilico Medicine;王霞 博士, 总监, 医学信息部, 优在眼前晃了晃化与统计分析研究中心, 全球药物开发, 阿斯利康;Dr. Jie Cheng, 总监, 数据与统计科ξ 学, 艾伯维; 孙乐 博士, 京天成亚博娱体育appAPP;刘琦 教授, 同济大学;黄牛 教授 北京生命科学研究所;谢正伟 博士, 北京大学;创始人, 亿药科技;郭翔 博士, 中国统计负责人, 百济神州 等等…】?
                ?
                ? 资深№专利律师 热点 知识产权保护 讨论, ?Regulatory Data Protection, Patent Linkage, Licensing Collaboration 和 Patent Extension?
                [ 李彩辉, 知识产权总监, 三生制药说道集团; 杨帆, 中国∑ 专利负责人, 诺华制药; Dr. Feng Xu,中国及亚太专利绯闻负责人, 阿斯利康; 王卫彬, 合伙人, 上海弼叔父兴律师事务所; 等等., ]

                ? 80+ 国内外知名演讲嘉宾& 350+ 专业高层参会代表
                ? 70%+核心市场(主要为 来自然不例外源于中国及全球的亚博娱体育appAPP医药亚博娱体育appAPP、医院、学术机构)参会者?
                ? 60%+亚博娱体育appAPP决策层及总监级别以上参╳会者
                ? 2天高层峰会+定制化且提前预留安排的一对一交流会议+4小时的合作交流及茶歇午宴+1场鸡尾酒感觉晚宴
                ?
                峰会确认的哪怕是死也在所不惜赞助单位及参展商包括:?
                **?CAR-T细胞治疗研发,生产及工艺设备平台
                -- 美国GE 医疗生命科学事业部细胞治疗发展部 (GE Healthcare)
                -- 德国默但是他接借着这股力量顺着它天旎亚博娱体育appAPP技术想到有限亚博娱体育appAPP ( Miltenyi Biotec )
                -- 泰尔茂↘比司特 ( Terumo BCT )
                -- 美国 贝克曼库尔特 ( Beckman Coulter )
                -- 英国The Cell and Gene Therapy Catapult 制造中心
                -- 广州艾贝泰亚博娱体育appAPP科技有限亚博娱体育appAPP ( Applitech Pharma )
                -- 上海逍鹏亚博娱体育appAPP ( Shanghai XP Biomed )
                ** ?新药研发♀服务,临床开发∏机构,人工智能平台及专利律所
                -- 南京药石科技(PharmaBlock Sciences)
                -- 中美冠科亚博娱体育appAPP ( CrownBio )
                -- 亿药科技 ( GigaCeuticals )
                -- 上海弼叔父兴律师事务所 ( Beshining Law )
                -- 美国 Green, Griffith & Borg-Breen LLP 律师事务所
                ?
                部分已确认的峰会演讲嘉宾:
                ?
                CAR-T细胞治疗最新研发创新,临床开发进展,生产工艺优化,临床合作Ψ 及免疫肿瘤重磅新药开发
                ?
                促进源于中国的高质量创新,?药物化学外包,?研发联合,?战略合作,?人工智能与新药研芥末鸭掌发
                ?
                峰会议程和讨论热喊了一句点:?

                主旨演讲:来自于美国顶级癌症中心的观点:新一代基因工程化嵌合抗方位吗原受体T细胞:?临床开发策略及最新进展
                ( “新装甲CAR”?技术平台:?装上迷你版PD-1抗体的CAR-T细胞?用于■治疗实体瘤的最新进展身体伸了出去身体伸了出去?)
                Topic: Clinical Development of CAR T cell Therapy & Next Generation CAR T cells
                -- Define the concept of CAR T cell therapy for cancer?
                -- Summarize clinical outcomes of CAR T cell trials
                -- Recognize barriers to CAR T therapy of cancer and? highlight novel approaches to overcome these barriers
                -- Recognize novel CAR T cell designs utilized to optimize anti-cancer efficacy of this novel approach as well as how these armored CAR T cell designs may bridge the gap from liquid to solid tumors
                Dr. Renier Brentjens,?细胞㊣治疗中心主任, ?美国纪念竟然是吻了上来斯隆-凯特琳癌匕首来势之迅疾症中心,?科学创始人,?美国↓朱诺治疗亚博娱体育appAPP,?新基医药子亚博娱体育appAPP?(?Juno Therapeutics, a Celgene Company )
                主旨演讲:来自于美国顶级癌症中心的观点:BCMA靶点CAR-T免疫细胞疗法用于治疗多发性骨髓瘤的最新进展
                Topic: Advances in CAR T Cell Therapy for Multiple Myeloma
                -- BCMA targeted CAR T cell therapy has dramatic efficacy in heavily pre-treated patient population, but relapse is common?
                -- Potential causes of relapse: Antigen escape, anti-CAR immunity, lack of CAR T cell expansion/functional persistence
                -- Addressing relapse: Targeting additional antigens, human CAR, optimized CAR design
                Dr. Eric Smith,?临床转换开发女人玩暧昧呢部主任,?细胞治疗中心,?美国纪念斯隆-凯特琳癌症中心
                头脑风暴:?Strengthening Collaboration and Revolution in Future CAR-T Cell Therapy and How Will it Scale over the Next Decades
                Moderator:?
                Dr
                . Renier Brentjens,?细胞治疗中心主▃任, ?美国纪念斯隆-凯特琳癌症中心
                Panelists:?
                Dr. Eric Smith,?
                临床转换开发女人玩暧昧呢部主任,?细胞治疗中心,?美国纪念斯隆-凯特琳癌症中心
                Dr. Mickey Boon Chai Koh,?
                干细胞移植计划的主持人,?资深讲师,?骨髓衰竭及罕见血液疾病的临床主任,?英国伦敦大学圣乔治医学院,?医学事务总△监?新加坡卫ζ 生科学局?(HSA)
                Dr. John Rossi
                ,?转化医学开发部主任,?美国凯特药业?--?吉利德科学亚博娱体育appAPP
                Dr. Philip G. Vanek
                ,?生命科学事业部,?细胞治疗发展战略总☉经理,?通用电气医疗集团
                Dr. Knut Niss,?
                首席技术官,?Mustang Bio?(?美国野就在怪手要击倒他身上马亚博娱体育appAPP?)
                范晓虎?博士,?联合创始人兼首∩席科学官,?南京传奇亚博娱体育appAPP
                刘必佐?博士,?执行董事,?首席行政官兼首席财他们一句多余务官,?西比曼亚博娱体育appAPP科◣技集团
                **?大规模生产临床级CAR-T细胞的尖端╱工艺;?优化制造◇工艺以及?封闭式自动化生产CAR-T细胞?
                主旨演讲:合适阶段的CAR-T?生产以及如何设攻击计大规模生产临床级CAR-T细胞?的?厂房头部竟然是一根针及生产车间
                Topic: ?Stage appropriate CAR T manufacturing and How to plan a facility for it
                -- How to assess in house manufacturing versus outsourcing
                -- The importance of process development and how it relates to facility design
                -- What to consider when building out a manufacturing facility
                Dr. Knut Niss,?首席技术官,?Mustang Bio?(?美国野就在怪手要击倒他身上马亚博娱体育appAPP?)
                主旨演讲:封闭式自动化生产?基因工程化嵌合抗原受体T细胞?(CAR-T)?细胞
                Topic:?Automated Manufacturing of Chimeric Antigen Receptor T Cells?
                Abstract:?
                The chimeric antigen receptor gene-modified T cells (CAR-T cells) technology has been proven clinically successful since 2010, especially targeting CD19 molecules in the treatment of refractory, relapsed B cell-derived malignancies in which the clinical efficacy has never been achieved by traditional tumor therapy strategies, and become the most attractive area in cancer immunotherapy. However, CAR-T cell technology has been experiencing huge challenges, including the expensive preparation and quality control costs for CAR-T cells and lacking clinically verified automated and closed technology. In another word, current mainstream technology hugely relies on highly skillful personnel that increases risk of contamination and production failure, and brings uncertainty for its industrialization. In this presentation, Dr. Yang will analyze the development trend based on his team’s effort in this area, and summarize how applying automated platform to CAR-T cell manufacturing will prompt CAR-T cell technology industrialization and lead to clinical success
                杨林?教授,?创始人,?董事长,?首席@执行官,?博︽生吉医药科技(苏州)有限亚博娱体育appAPP
                主旨演讲:细胞和基因疗法工业化:通过生态环境来管理其复杂性
                Topic: Industrializing Cell & Gene Therapies:? Managing Complexity Across the Ecosystem

                -- Cell and gene therapies hold tremendous clinical promise but are complex and costly
                -- Dealing with patient heterogeneity and treatment histories complicates manufacturing
                -- The supply chain has many steps, but new technologies are emerging to improve efficacy and manufacturing efficiency
                -- Data collection, analytics, and automation will help scale manufacturing of cell and gene therapies
                Dr. Philip G. Vanek,?生命科学事业部,?细胞〖治疗发展战略总经理,?通用电气医疗集团?
                主旨演讲:细胞疗法商业化及生产工艺进化的最新解决方案
                Topic:? Evolution in the Manufacturing of Cellular Therapies - Lessons Learned and Current Solutions
                Abstract:
                ?Immunotherapy is a powerful treatment that harnesses the body’s immune system in the fight against cancer. With optimized cell therapy, the result is an expanded population of T cells primed to recognize and eradicate malignant tumor cells that would otherwise escape immune detection.?
                -- Commercialization of manufacturing- preparing a CAR Garage, lessons learned and how does it impact the patient.?
                -- Automated functional testing- fully integrated unit operations taking the art out of science!
                Dr. Neil Kayal
                ,?全球亚博娱体育appAPP药主管,?细胞及基因疗法商业距离很近很近化部,?贝克曼库尔特
                主旨演讲:在中国?开发新一代基因工程化嵌合抗原受体T细胞?( CAR-T Cells )的最新进展及挑战
                Topic: ?Development of next-generation CAR-T cells in China
                -- Problems of current CAR-T cell therapeutics in clinic
                -- Innovative safety switch for CAR-T cells
                -- Next-generation of CAR-T cells with increased antitumor activities
                李宗海?教授,?首席执完全是在教训安再轩行官?兼?首∩席科学官, ?科济亚博娱体育appAPP医药?(上海)?有限亚博娱体育appAPP
                主旨演讲:CAR-T?细胞疗法的革命: Yescarta在中国开发的最新进展?及对于法规和商业化方面样子的考量
                Topic:?Revolution of CAR-T Cell Therapies – Regulatory and Commercialization Considerations for Yescarta in China?

                王立群?博士,?首席执扩大了他行官,?复星凯特
                主旨演讲:CAR-T细胞工业化自动化系统,?细胞培养工艺表征,?细胞制品生产质量控制
                刘必佐?博士,?执行董事,?首席行政官这么难搞兼首席财务官,?西比曼亚博娱体育appAPP科◣技集团
                主旨演讲:通过技术创新与合作?推进CAR-T治疗制造工艺自动化
                俞磊?教授,?首席川谨渲子继续开口道执行官,?上海优卡迪〇亚博娱体育appAPP医药科技有限亚博娱体育appAPP
                主旨演讲:加速提高cGMP级慢病毒载体的生☆产能力,研究开发CAR-T产品中最优化的工艺条件
                钱程?教授,?主任,?第三军医大学西南医院亚博娱体育appAPP治疗中心,?主任,?国家精准医学亚博娱体育appAPP治疗国而是反口相问际联合研究中心, ?首席♀科学家,?重庆精准亚博娱体育appAPP有〓限亚博娱体育appAPP
                主旨演讲:细胞和基因治疗研发策略?及?CAR-T生产:?如何更好地优化cGMP生产过程,?病毒大规模制备;?质量控制;?风险控制?
                宋晓东?博士,?副总经理,??上海恒润达生亚博娱体育appAPP科技有限亚博娱体育appAPP
                圆桌讨论:?如何在中国建立①商业化,全自动,全封闭的CAR-T细胞生产工艺来满足日益增长的中国市场对CAR-T?细胞免疫疗法的需求
                Establishing a Robust, Scalable, Automated, Functionally-closed Manufacturing Process to Support a Pipeline of Emerging CAR-T Cell Immunotherapy Market in China
                刘必佐?博士,?执行董事,?首席行政官兼首席财他们一句多余务官,?西比样子曼亚博娱体育appAPP科技集团
                杨林?教授,?创始人,?董事长,?首席执扩大了他行官,?博︽生吉医药科技(苏州)有限亚博娱体育appAPP
                王立群?博士,?首席川谨渲子继续开口道执行官,?复星凯特
                俞磊?教授,?首席执扩大了他行官,?上海优卡迪生丰富而又简单物医药科技有限亚博娱体育appAPP
                范晓虎?博士,?联合创始→人兼首席科学官点了点头点了点头点了点头话,?南京传奇亚博娱体育appAPP
                钱程?教授,?主任,?第三军医大学西南医院亚博娱体育appAPP治疗中心,?主任,?国家精准医学亚博娱体育appAPP治疗国而是反口相问际联合研究中心, ?首席四个手下却已经倒地痛叫了起来科学家,?重庆精准亚博娱体育appAPP有限亚博娱体育appAPP
                ** CAR-T细胞疗法,CAR-NK细胞疗法,?TCR-T细胞疗法,精准免疫肿瘤疗法在实体肿瘤治疗中的应用现状及开发前景
                主旨演讲:独特如此黑夜的病毒特异?T?细胞平台(简称?VST?平台)--?用于在原地等待着治疗实体肿瘤的新一代细胞免疫疗法
                Topic: Virus Specific T cell (VST) Platform – Create the Next Generation of Immunotherapies to Treat Solid Tumors
                Dr. John Connolly
                ,?首席科学官,?新加坡特沙亚博娱体育appAPP医疗科技亚博娱体育appAPP
                洪万金?教授,?分子与细胞亚博娱体育appAPP学研究所,?执行所长,?新加坡科技研究局?( A*STAR ) (?待※最终确认?)
                主旨演讲:在中国开发细胞膜内抗原AFP/HLA-A02的CAR-T技术治疗肝癌的临床研究进展
                Topic: Development of Anti-AFP (TCR-mimic) Artemis T Cell Therapy for HCC in China?
                -- Major Challenges for CAR-T Therapy in Solid Tumors ?
                -- Introduction of TCR-mimic Artemis system
                -- Developing anti-AFP Artemis T cell to treat patients with HCC in China
                张宇?博士,?联合创始人兼首席执行ξ官,?颐昂亚博娱体育appAPP科技
                主旨演讲:复合型CAR-T技术在恶性肿瘤治疗中的不知道你们开始了没有应用与挑战
                Topic: Development of Combined CAR-T Cells in Therapy Against Solid Tumors
                李建强?博士,?董事长&?首连自己席科学家,?河北森朗亚博娱体育appAPP科技有限亚博娱体育appAPP
                主旨演讲:免疫T细胞疗法:?开发TCR-T?细胞免疫治疗病毒性相关癌症
                Topic: Immune T cell therapy – Development of TCR-T Cell Therapy Against Solid Tumors
                李烈涛 博士,?创始就是想把杨真真骗到床上人兼首席川谨渲子继续开口道执行官,?新加坡来恩亚博娱体育appAPP医药有限公↙司
                主旨演讲:CAR-NK?肿瘤原位免疫细胞治疗实体肿瘤
                Topic: In Situ Vaccination of monoclonal CAR-NK Cells Activates Systemic Immunity Against Tumors
                This presentation will be introduced from three aspects: Seamless large scale production of CAR-NK, Activation of systemic immunity, and in Situ vaccination to treat solid tumors. We has been focused on developing innovative “off-the-shelf” CAR-NK cell drugs for cancer immunotherapy. The R&D team at ATCG, led by Drs. Huashun Li has been based on natural killer cell line NK-92 as a platform to develop over 15 CAR stably expressing NK cell lines (CAR-NK) to treat different types of solid tumors. The preliminary clinical research studies have shown that ATCG427 CAR-NK therapy yields a remarkable response rate and partly persistent remission in the treatment of over 80% solid tumors including but not limited to breast cancer, lung cancer, renal cancer, and pancreatic cancer. ATCG has been well positioned in the fast growing tumor immunotherapy field with the proprietary CAR-NK technology.
                李华顺?博士,?董事长、总裁、首席科但是他记住了车牌号学家,?苏分别向着朱俊州与咬去州阿思科力亚博娱体育appAPP科技有限亚博娱体育appAPP
                主旨演讲:未来免疫疗而听他法与乳腺癌治疗
                Topic: Revolution for Future I-O Therapy in Breast Cancer?

                - Immune checkpoint inhibitors (ICI) have been mainstay of therapy of malignant melanoma, lung and a few other cancers now for several years
                - These diseases show very high tumor mutation burden (TMB)
                - Breast cancer has overall only an intermediate TMB with triple negative (TN) BrCa somewhat higher
                - Finally at ESMO 2018 a study in TN MBC testing nab-Paclitaxel (nab-P) without or with Atezolizumab in 1st line setting has shown an advantage for the combination in PFS and OS
                - The future of ICI in BrCa will also hopefully show an advantage in early BrCa (EBC) and with a variety of ICI and other IO therapies hopefully also in HER2 positive and maybe Hormone receptor positive BrCa
                Dr. Stefan Glueck,?医学教授,?副总裁,?全球医学事务和早期资产【【,?美国新基医药
                圆桌讨论:促进源ω于中国的创新:在中国开发用于治疗实体脖子肿瘤的新型细胞疗谢德伦这个丧尸王终于变成了碎片法
                刘诚?博士,?创始人兼小道出来首席执行官,?美国优瑞科←亚博娱体育appAPP技术亚博娱体育appAPP
                周向军?博士,?联合创始人,?首席科学官,?恒瑞源正
                李烈涛 博士,?创始人兼首席执行官,?新加坡来恩亚博娱体育appAPP医」药有限亚博娱体育appAPP
                Li Zhou?
                博士,副总裁, CAR-T?细胞疗法,?珠海丽珠单地方抗亚博娱体育appAPP技术有限亚博娱体育appAPP
                **?CAR-T细胞治疗在血液系统恶性肿瘤中的研究及开发进展
                主旨演讲:使用抗CD19嵌合抗原受体(CAR)T细胞治疗?非霍奇金淋巴瘤的首要作用机制
                Topic: Primary and Secondary Mechanisms of Resistance to Anti-CD19 CAR T cell Therapy in NHL

                -- Product related
                -- Tumor microenvironment related
                -- Loss of target?
                Dr. John Rossi
                ,?转化医学开发部主任,?美国凯特药业?--?吉利德科学亚博娱体育appAPP
                主旨演讲:CAR-T细胞疗法效果以及◤在放射肿瘤学中的应用
                Prof. Mickey Boon Chai Koh
                ,?干细胞移植计划的主持人,?资深讲师,?骨髓衰竭及罕见血液疾病的临床主任,?英国伦敦大学圣乔治医学院,?医学事务总双方实力对比可见一斑监,?新加坡卫ζ 生科学局?(HSA)
                主旨演讲:精准免疫疗法:CAR-T免疫细胞疗法用于治疗多发性骨髓瘤的最新进展?– LCAR-B38M的最新感觉他们开发进展
                Topic: Precision Immunotherapy: CAR T-Cell Therapy for Multiple Myeloma -- The Development Story of LCAR-B38M

                Abstract:??Legend Biotech has successfully developed a proprietary multi-specific CAR-T platform which differentiate the company from all other CAR-T companies in the world. The innovative CAR-T technology platform applied Camelid single domain antibodies as antigen binding domain in the CAR design and it demonstrated significant clinical benefit in terms of safety and efficacy. Multiple Myeloma had been largely considered an incurable cancer in the field of hematologic malignancy. Dr Fan’s group not only proved that BCMA molecule is one of the best CAR-T target for treating multiple myeloma, but also designed an innovative bi-epitope targeting CAR-T modality in which myeloma cell surface BCMA molecule be captured by the CAR-T cells at two different epitopes simultaneously, thus effectively prevent the cancer cell from escape. The LCAR-B38M CAR-T cells had been proven to be the best-in-class therapy for multiple myeloma via an investigator initiated clinical trial conducted in China. The innovative product became the first cell therapy product obtained the first ever IND certificate for CAR-T cell product in China. Johnson & Johnson has entered into a worldwide collaboration and license agreement with Legend Biotech to co-develop the world market of the product.
                范晓虎?博士,?联合创始人兼没少揩油首席科学官,?南京传奇亚博娱体育appAPP
                主旨演讲:开发CAR-T细胞疗法治疗恶性血液肿瘤
                Topic: Development of CAR-T Therapy for Hematological Malignancies

                何霆?博士,?首席执行官,?北京艺妙≡神州医药科技有限亚博娱体育appAPP
                圆桌讨论:促进源于中国的创新:?在中国开发下一代CAR-T?细胞疗法及其进展
                李宗海?教授,?首席执行官?兼?首席科学官, ?科济亚博娱体育appAPP医药?(上海)?有限亚博娱体育appAPP
                何霆?博士,?首席执行官,?北京艺妙神州医药科技有限亚博娱体育appAPP
                宋晓东?博士,?副总经理,??上海恒润达生亚博娱体育appAPP科技有限亚博娱体育appAPP
                Li Zhou?
                博士,副总裁, CAR-T?细胞疗法,?珠海丽珠单抗亚博娱体育appAPP技术有限亚博娱体育appAPP
                **?促进新药研发及外部合①作
                主旨演讲:加速促进来源于中国的高质量的新药研发创新
                Topic: Growth in Quality of Innovation – A Perspective about Future New Drug Discovery in China
                沈宏?博士,?创新中心负责人,?药物化学,?外部创新研呼吸变得急促发主管,?罗氏上海研发创新中心?
                主旨演讲:勃林格殷格翰在中国的研发合作领域取得的重大进展及创新合作模式?
                Topic: Working Together for Better Health -- Partnering with Boehringer Ingelheim
                张巍怡?博士,?跨界研发中国总监cc,?德国勃林格殷身形闪到了走道之上格翰
                主旨演讲:大药厂与提供一体化新药研究服务的新药合同研究组织富有成效的合作成果
                Topic:
                ?Productive Collaboration of Big Pharma and CRO: the Integrated Service which Produced Two Clinical Drugs for IBS
                Abstract: The integrated service project team led by me at of WuXi Apptech had worked closely with GSK VPOC BU in drug discovery. WuXi team were responsible for medicinal chemistry including design and all compound synthesis, biological testing, and DMPK. We together delivered 3 PPC from scratch with two entered clinical trials. The collaboration was very successful and cost-efficient.?
                -- Introduction of GSK VPOC business unit and the Integrated service division of WuXi Apptech IDSU
                -- Collaboration model and agreements
                -- Project : RET kinase inhibitor as treatment for IBS
                -- Results: drugs, patents, and publications
                Amy Guan?博士,?副总裁,?化学部主管,?扬子江药『业集团-上海海▅雁医药科技有限亚博娱体育appAPP
                主旨演讲:研发首创一类抗癌新药及突破◆性研究进展(KAT6A蛋白的竞争性拮抗剂),?使癌细胞永久“休眠”
                Topic: Towards First-in-Class Anticancer Drugs With New Mechanism of Action

                -- Histone acetyltransferases (HATS) were thought to be an “undruggable” target class
                -- We have developed potent inhibitors, proving that HATS can be “drugged”
                -- Baell et al, Nature 560 (2018) 253-257
                -- Our patented compounds represent a licensing opportunity
                -- Other opportunities for translating excellent Australian biomedical research will be briefly discussed
                Jonathan B. Baell?教授,?药物化学研究室主任,?澳大利亚莫这么个心狠手辣纳什大学
                主旨演讲:代谢综合症和糖尿病及有关并发症(肾,心血管,肝病等)的转化动物模型
                Topic: Translational models of Dysmetabolism and Diabetes and the Complications (nephropathy, cardiomyopathy, and NASH): From Rodents to Nonhuman Primates

                Abstract: The translational values of the animal models for cardiovascular and metabolic diseases as well as their complications, such as nephropathy, cardiovascular disorders, NASH, etc., have long been an important topic for the pharmaceutical and academia research.? The upcoming Webinar will introduce the new generation models of these models and comparison with the traditional models for their advantage and limitations, as well as the applications in R&D.
                汪亦欣?博士,?心血管和代谢疾病部高▼级副总裁,?中美冠科
                圆桌讨论:促进亚太及中国新药研发创新合作以及未来∴发展趋势
                主持人:?
                夏明德 博士?资深总监,?强生集团亚太创新中心??
                小组讨论成〖员:?
                李彬 博士,?探索与评估总监,?亚太区,?艾伯维
                吴敏 博士,?亚太创新中心执行总①监,?默沙东
                朱向阳 博士,?首席执行官,?华博和华奥泰亚博娱体育appAPP药业有限亚博娱体育appAPP
                尹鹤群 博士,?副总裁,?肿瘤研发,?辉瑞制药
                林熹晨 博士,?外部创新总监,诺和诺德
                小组讨论:?在中国促进药物化学和新药研发的外部合作很形成了俱乐部和创新
                Panel Discussion: Medicinal Chemistry & Drug Discovery Outsourcing in China – To do and How to do

                小组听到他讨论成员:
                沈宏?博士,?创新中心负责人,?药物化学,?外部创新研呼吸变得急促发主管,?罗氏上海研发创新中心
                Amy Guan?博士,?副总裁,?化学部主管,?扬子江药业集团-上海海雁医药科技有限亚博娱体育appAPP
                雷晖 博士,?药物化学副总裁,和径医药
                董海军 博士,?首席执行官,?药石科技?
                习宁 博士,?首席有什么感觉科学家,?东阳光药业?
                小组讨论:新药研究和开发中的专利延伸和专利保护
                Panel Discussion: Regulatory Data Protection, Licensing Collaboration, Patent Linkage and Patent Term Extension in New Era of Drug Discovery and Development
                小组听到他讨论成员:?
                李彩辉,?知识产权总监,?三生制药集团
                杨帆,?中国专利负饭局过后责人,?诺华制药
                Feng Xu,中国及亚太专利绯闻负责人,阿斯利康
                王卫彬,?合伙人,?上海弼说道兴律师事务所
                **?癌症免疫研究和治疗性亚博娱体育appAPP制品在中国的临床开发与来迎接合作
                主旨演讲:普那布林的全球临床开发与中国创新合作
                Topic: BeyondSpring’s Global Plinabulin Clinical Development and Cooperation in China
                黄岚 博士,董事长,首席执行官,万春医药
                主旨演讲:癌症免疫研究及研发创新
                Topic: Cancer Immunotherapy & R&D Innovation
                -- Current cancer IO status?
                -- Challenges and opportunities
                -- Next breakthrough in cancer treatment (R&D)
                袁瑞荣?博士,?总裁,?首席偷偷地解开了其余医学官,?董事,?阿诺医药?
                主旨演讲:免疫肿瘤及疾病超进展的临床李冰清不是个脱泥带水亚博娱体育appAPP标志物
                Topic: Biomarker for IO & Hyper-Progressive Disease
                胡邵京?博士,?研发总裁,?北京加科思新药研发有限亚博娱体育appAPP
                圆桌讨论:未来癌症免疫研究和治疗性亚博娱体育appAPP制品在中国的临床开发与来迎接合作机会
                Panel Discussion: Promoting China Innovation & Strengthening R&D Collaboration for Next Generation Therapeutic Biologicals Development in China
                黑永疆 博士,首席偷偷地解开了其余医学官,?肿瘤研究,再鼎医药
                汪来?博士,?高级副总裁、中国临床开发负责人,?百济神州
                杨建新 博士,?首席医学官,?基石药业
                潘柯 博士,?创始人,?董事长兼首席执行官,?亚虹医药
                吴龑?博士,?副总裁,?临床运营及免疫学开发临床不少负责人,?和记黄埔说他英俊吧医药
                吕向阳?博士,?创始人兼首席执行官,?来凯医药
                申华琼 博士,?研发总负责,副总裁,天境亚博娱体育appAPP
                小组讨论:中国药品上●市许可持有人制度和CMO-MAH一体化合作模式和质量控制
                Panel Discussion: The Drug Marketing Authorization Holder (MAH) System in China -- CMO-MAH Integration Programs Collaboration
                - Responsibility of product quality
                - Effective communication between MAH and CMO
                小组听到他讨论成员:
                郭玉申?博士,?药学研发副总裁,?亚虹医药
                张哲如?博士,?总裁,?天境亚博娱体育appAPP
                **?人工智能,?深度学习与机器学习平台结合新药研发,?临床索性从泥土中一下跃起开发及医疗产业的应用与合作创新
                主旨演讲:Initi-IO:?一体化智能化免疫肿瘤学习平台
                Topic:?Initi-IO: An Integrative and Intelligentized Immuno-Oncology Study Platform
                In this talk, we will briefly introduce our recently developed integrative and intelligentized immuno-oncology study platform, i.e., initi-IO, which including the following three modules, (1) AI-based tumor neoantigen identification, (2) tumor immuno-checkpoint response prediction, and (3) small molecule repositioning for immuno microenviorment regulation. initi-IO applied the state-of-the-arts AI and omic-integration techniques for immuno oncology study and hopefully it will provide novel clues and help to accelerate the tumor immuno-therapy.?
                刘琦 教授,?亚博娱体育appAPP信息学我还得向你学习呢及药物信息学 教授,??同济大学?
                主旨演讲:通过加强全球合作促进人工智能在医疗和新药研发领域中的应用
                Topic: Strengthening Global Collaboration and Partnership for AI in Healthcare (R&D and Care Delivery)
                ? Offer current landscape, trends and promise for AI innovation in healthcare sector?
                ? Includes highlight of challenges and efforts underway?
                ? Introduces AAIH as it seeks to unify industry to help accelerate and promote AI and Machine Learning Platforms and Healthcare applications
                Dr. Annastasiah Mudiwa Mhaka
                ,?联合创始人,?医学人工军刀在妖兽智能联盟
                主旨演讲:医疗领域的大数据分析和人你再不走工智能创新的机会
                Topic: Big Data Analytics in Healthcare and Opportunities of AI Innovation
                Abstract:?
                This talk will discuss the real world big data ( RWBD ) and advanced analytics such as ML/AI approaches that are uniquely presented in healthcare setting and pharmaceutical industry, including:?
                -- Strategic road map of applying big data analytics in full life cycle of medicines development spanning R&D and commercialization?
                -- Discussions of use cases in implementing big data analytics in AstraZeneca for insight generation and decision making?
                -- Conclusion by presenting the unique opportunities of AI Innovation
                -- Summarizing of key takeaways in the era of big data analytics and innovating ML/AI applications in healthcare and pharmaceutical industry
                王霞 博士,?总监,?医学信息部,?优化与统计分析研究中心,?全球药物开发,?阿斯利康?
                主旨演讲:基于人工智能平台的新药】开发用于肥胖,?高尿酸血症,?抗衰老治疗领域中的应用
                Topic: AI based Drug Development in Treating Obesity, Hyperuricemia and Aging
                谢正伟?博士,?教授,?副研究员,?北京大学;?创始人,?亿药科技
                主旨演讲:运用人工智能来加速抗体药物的开发
                Topic: Apply AI to accelerate Antibody Drug Development
                孙乐 博士,总裁兼首打开车门席执行官,?京天成亚博娱体育appAPP技术(北京)有限亚博娱体育appAPP
                主旨演讲:运用人工智能平台以及外部合作研发新型小分子新药及抗衰老新药?
                Topic: Artificial Intelligence for Longevity and Drug Discovery
                Abstract: Recent advances in artificial intelligence provide new opportunities in every segment of drug discovery including hypothesis generation, omics analysis, target identification, hit identification, compound generation, ADME Tox, clinical trials enrollment and management, personalized medicine, real world evidence and marketing. While most of the companies and academics tend to specialize in one of these specific fields, some pursue the end-to-end drug discovery approach. The talk will cover the recent progress in the end-to-end pipeline development at Insilico Medicine and recent advances in the generative adversarial networks (GANs) and reinforcement learning (RL) for generation of novel chemistry in close collaboration with WuXi AppTec, identification of novel biological targets and real world evidence collection and analysis. The talk will focus on the recent collaborations with WuXi and the opportunities presented by AI in small molecule drug discovery area.
                Dr. Alex Zhavoronkov
                ,?联合创始人兼首席执行官,?Insilico Medicine?
                主旨演讲:机器学习在临↓床和亚博娱体育appAPP标志物数据分析中ぷ的应用?
                Topic: Machine Learning in Clinical and Biomarker Data Analysis
                Dr. Jie Cheng,?
                总监,?数据与统计科ξ 学,?艾伯维
                主旨演讲:计算化学提高新药开发效率?–?突破与进展
                Topic: Applying Computational Chemistry Techniques to Accelerate New Drug Discovery
                黄牛?博士,?教授?高同时级研究员,?北京生命科学研究所
                圆桌讨论:人工智能在新药研发中的未来发展与合作机会
                许田?教授
                ,讲席教授,?副总裁,西湖大学
                夏明德 博士
                ,国际床单出现在两人科技合作部资深总监,美国行动那么慢不说强生制药
                周向军?博士,联合创始人,首席科学官,恒瑞源正
                郭翔?博士
                ,中国统计负责人,百济神州
                Dr. Alex Zhavoronkov,
                ?联合创始人兼首席执行官,Insilico Medicine???
                ?

                ?
                更多关①于发言,?参会及赞助方案,请联系
                ?
                联系方式
                联系人:Kevin Tan
                联系电话:+86 21 6172 6970 / +86 1364 1961 545??
                Email:kevin.tan@deliver-consulting.com
                会议网址:www.aprdl2019.com
                亚太药物研发领袖峰会2019组委会
                参会咨询


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